4-desfluoro-3-deschloro Afatinib

CAS No: NA
Chemical Name:
(S,E)-4-(dimethylamino)-N-(4-(phenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)but-2-enamide
Molecular Formula:
C24H27N5O3

Impuroty-14

CAS No: NA
Chemical Name:
7-fluoro-6-nitro-N-phenylquinazolin-4-amine
Molecular Formula:
C14H9FN4O2

Impuroty-10

CAS No: 2512206-82-3
Chemical Name:
N-(3,4-dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Molecular Formula:
C14H7Cl2FN4O2

Impurity-11

CAS No: 2475095-50-0
Chemical Name:
N-(4-chloro-3-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Molecular Formula:
C14H7ClF2N4O2

Impuroty-12

CAS No: NA
Chemical Name:
N-(3-chlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Molecular Formula:
C14H8ClFN4O2

Impuroty-13

CAS No: NA
Chemical Name:
7-fluoro-N-(4-fluorophenyl)-6-nitroquinazolin-4-amine
Molecular Formula:
C14H8F2N4O2

Impurity-9

CAS No: 2226537-61-5
Chemical Name:
N-(3,4-difluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Molecular Formula:
C14H7F3N4O2

3-Fluoro-4-chloro

CAS No: 2406199-31-1
Chemical Name:
(S,E)-N-(4-(4-chloro-3-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C24H25ClFN5O3

Impuroty-6

CAS No: NA
Chemical Name:
(S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)acetamide
Molecular Formula:
C20H18ClFN4O3

Impuroty-7

CAS No: 2121530-37-6
Chemical Name:
(S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-hydroxybut-2-enamide
Molecular Formula:
C22H20ClFN4O4

Impuroty-8

CAS No: 162012-69-3
Chemical Name:
7-fluoro-6-nitroquinazolin-4(3H)-one
Molecular Formula:
C8H4FN3O3

Nitro sopositional isomer

CAS No:  2475094-96-1
Chemical Name:
N-(4-chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine
Molecular Formula:
C14H7ClF2N4O2

3-Chloro Afatinib

CAS No: NA
Chemical Name:
(S,E)-N-(4-(3-chlorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C24H26ClN5O3

N-Desmethyl

CAS No: 2413212-13-0
Chemical Name:
(S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide
Molecular Formula:
C23H23ClFN5O3

Nitro R-Isomer

CAS No: 402855-07-6
Chemical Name:
(R)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Molecular Formula:
C18H14ClFN4O4

R-Isomer

CAS No: 945553-91-3
Chemical Name:
(R,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C24H25ClFN5O3

4-Fluoro Afatinib

CAS No: 2413212-25
Chemical Name:
(S,E)-4-(dimethylamino)-N-(4-(4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)but-2-enamide
Molecular Formula:
C24H26FN5O3

Dichloro Afatinib

CAS No: 2223677-63-0
Chemical Name:
(S,E)-N-(4-(3,4-dichlorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C24H25Cl2N5O3

Impurity-4

CAS No: 618061-76-0
Chemical Name:
(S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate
Molecular Formula:
C24H27ClFN4O6P

N-Oxide

CAS No: 2413212-11-8
Chemical Name:
(S,E)-4-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide
Molecular Formula:
C24H25ClFN5O4

Impurity-5

CAS No: 1456696-14-2
Chemical Name:
(S,E)-4-(dimethylamino)-N-(4-oxo-7-(tetrahydrofuran-3-yloxy)-1,4-dihydroquinazolin-6-yl)but-2-enamide
Molecular Formula:
C18H22N4O4

Difluoro Afatinib

CAS No: 2223677-62-9
Chemical Name:
(S,E)-N-(4-(3,4-difluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C24H25F2N5O3

Butoxy impurity

CAS No: NA
Chemical Name:
(E)-N-(7-butoxy-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C24H27ClFN5O2

N-formyl impurity

CAS No: 2223677-60-7
Chemical Name:
(S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)formamide
Molecular Formula:
C19H16ClFN4O3

Impurity-1

CAS No: 314771-88-5
Chemical Name:
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Molecular Formula:
C18H14ClFN4O4

Impurity-2

CAS No: 314771-76-1
Chemical Name:
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine
Molecular Formula:
C18H16ClFN4O2

Impurity-3

CAS No: 1449430-45-8
Chemical Name:
4-(3-chloro-4-fluorophenylamino)-6-nitroquinazolin-7-ol
Molecular Formula:
C14H8ClFN4O3

Reference standard

CAS No: 850140-72-6
Chemical Name:
(S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C24H25ClFN5O3

Sulfonic acid analogue

CAS No: 2283295-16-7
Chemical Name:
4-(4-(3-chloro-4-fluorophenylamino)-7-((S)-tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-1-(dimethylamino)-4-oxobutane-2-sulfonic acid
Molecular Formula:
C24H27ClFN5O6S

Hydroxy impurity

CAS No: 2223677-58-3
Chemical Name:
1-(4-(3-chloro-4-fluorophenylamino)-7-((S)-tetrahydrofuran-3-yloxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Molecular Formula:
C22H20ClFN4O4

Methoxy impurity

CAS No: 1245555-42-3
Chemical Name:
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C21H21ClFN5O2

Ethoxy impurity

CAS No: 2085843-51-0
Chemical Name:
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Formula:
C22H23ClFN5O2