Impurity-6

CAS No:     98-97-5
Chemical Name:
pyrazine-2-carboxylic acid
Molecular Formula:
C5H4N2O2

Bortezomib intermediate-S-iomer

CAS No: 2363753-29-9
Chemical Name:
(S)-3-Methyl-1-((3aR,4R,6R,7aS)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-amine 2,2,2-trifluoroacetate
Molecular Formula:
C17H29BF3NO4

Bortezomib intermediate-R-iomer

CAS No: 179324-87-9
Chemical Name:
(R)-3-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-amine 2,2,2-trifluoroacetate
Molecular Formula:
C17H29BF3NO4

Impurity-3

CAS No: 85167-14-2
Chemical Name:
(3aS,4S,6S,7aR)-2-((S)-1-Chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
Molecular Formula:
C15H26BClO2

Impurity-4

CAS No: 514820-48-5
Chemical Name:
1,1,1-Trimethyl-N-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)-N-(trimethylsilyl)silanamine
Molecular Formula:
C21H44BNO2Si2

Impurity-5

CAS No: 84110-34-9
Chemical Name:
(3aS,4S,6S,7aR)-2-isobutyl-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
Molecular Formula:
C14H25BO2

Bortezomib R,S-hydroperoxide

CAS No: NA
Chemical Name:
N-((R)-1-((S)-1-hydroperoxy-3-methylbutylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Molecular Formula:
C19H24N4O4

Bortezomib R,R-hydroperoxide

CAS No: NA
Chemical Name:
N-((R)-1-((R)-1-hydroperoxy-3-methylbutylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Molecular Formula:
C19H24N4O4

USP Bortezomib R,S-diasteriomer

CAS No:  1132709-16-0
Chemical Name:
(S)-3-methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid
Molecular Formula:
C19H25BN4O4

Bortezomib Keto impurity R-isomer

CAS No: NA
Chemical Name:
(R)-N-(1-(3-methylbutanamido)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Molecular Formula:
C19H22N4O3

Bortezomib Double bond impurity

CAS No: 862895-00-9
Chemical Name:
(S,E)-N-(1-(3-methylbut-1-enylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Molecular Formula:
C19H22N4O2

Impurity-1

CAS No: 205393-22-2
Chemical Name:
(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate
Molecular Formula:
C29H39BN4O4

Impurity-2

CAS No: 73058-37-4
Chemical Name:
(S)-methyl 3-phenyl-2-(pyrazine-2-carboxamido)propanoate
Molecular Formula:
C15H15N3O3

USP Bortezomib R-hydroperoxide (RCL)

CAS No: 886979-78-8
Chemical Name:
N-((S)-1-((R)-1-hydroperoxy-3-methylbutylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Molecular Formula:
C19H24N4O4

USP Bortezomib S-hydroperoxide (RCM)

CAS No: 886979-81-3
Chemical Name:
N-((S)-1-((S)-1-hydroperoxy-3-methylbutylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Molecular Formula:
C19H24N4O4

USP L-Phenyl alanylanalog (RCO)

CAS No: 1194235-41-0
Chemical Name:
(R)-3-methyl-1-((S)-3-phenyl-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butylboronic acid
Molecular Formula:
C28H34BN5O5

USP D-Phenyl alanylanalog (RCP)

CAS No: NA
Chemical Name:
(R)-3-methyl-1-((R)-3-phenyl-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butylboronic acid
Molecular Formula:
C28H34BN5O5

Bortezomib Keto impurity

CAS No: 862894-96-0
Chemical Name:
(S)-N-(1-(3-methylbutanamido)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Molecular Formula:
C19H22N4O3

USP Bortezomib S,S-diasteriomer (RCG)

CAS No: 1132709-14-8
Chemical Name:
(S)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid
Molecular Formula:
C19H25BN4O4

USP Bortezomib R,R-diasteriomer (RCH)

CAS No: 1132709-15-9
Chemical Name:
(R)-3-methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid
Molecular Formula:
C19H25BN4O4

USP Hydroxy Bortezomib(RCC)

CAS No: NA
Chemical Name:
(R)-3-hydroxy-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid
Molecular Formula:
C19H25BN4O5

API reference standared

CAS No: 179324-69-7
Chemical Name:
(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid
Molecular Formula:
C19H25BN4O4