Impurity-8

CAS No: 2653-16-9
Chemical Name:
2-Chloro N-methyl-N-(4nitrophenyl)Acetamide
Molecular Formula:
C9H9ClN2O3

EP-E

CAS No: NA
Chemical Name:
(E)-methyl 3-((4-(2-(4-((E)-(6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)piperazin-1-yl)-N-methylacetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C47H42N6O7

EP-D

CAS No: NA
Chemical Name:
(E)-methyl 1-(2-methoxy-2-oxoethyl)-3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C34H37N5O6

Desmethyl Nintedanib

CAS No: 894783-61-0
Chemical Name:
(Z)-methyl 3-((4-(2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C30H31N5O4

Impurity-7

CAS No: 1235004-99-5
Chemical Name:
Methyl-2-oxoindole-6-carboxylate
Molecular Formula:
C10H7NO3

Dimer/EP-F

CAS No: 2410284-90-9
Chemical Name:
Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))(3Z,3'E)-bis(2-oxoindoline-6-carboxylate)
Molecular Formula:
C56H52N8O8

Impurity-3

CAS No: 1253769-13-9
Chemical Name:
(E)-methyl 1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C20H17NO5

Impurity-4

CAS No: 1987887-92-2
Chemical Name:
(Z)-methyl 3-((4-(methylamino)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C24H21N3O3

Impurity-5

CAS No: 262368-25-2
Chemical Name:
N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide
Molecular Formula:
C13H20N4O

Impurity-6

CAS No: 2243384-71-4
Chemical Name:
N-(4-aminophenyl)-N-methyl-2-(piperazin-1-yl)acetamide
Molecular Formula:
C13H20N4O

4-Hydroxy phenyl analog

CAS No: 2519501-85-8
Chemical Name:
(Z)-methyl 3-((4-hydroxyphenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C23H18N2O4

N-acetyl impurity

CAS No: 2380229-45-6
Chemical Name:
(Z)-methyl 1-acetyl-3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C33H35N5O5

Nitro dimer

CAS No: 2410649-54-4
Chemical Name:
2,2'-(piperazine-1,4-diyl)bis(N-methyl-N-(4-nitrophenyl)acetamide)
Molecular Formula:
C22H26N6O6

Impurity-2/EP-A

CAS No: 262368-30-9
Chemical Name:
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Molecular Formula:
C14H22N4O

Nitro impurity

CAS No: 1139453-98-7
Chemical Name:
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Molecular Formula:
C14H20N4O3

N-Oxide-1

CAS No: NA
Chemical Name:
(Z)-1-(2-((4-((6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methylamino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide
Molecular Formula:
C31H33N5O5

N-oxide-2

CAS No: 2734666-06-7
Chemical Name:
(Z)-4-(2-((4-((6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methylamino)phenyl)(methyl)amino)-2-oxoethyl)-1-methylpiperazine 1-oxide
Molecular Formula:
C31H33N5O5

Amine dimer

CAS No: 2410284-89-6
Chemical Name:
2,2'-(piperazine-1,4-diyl)bis(N-(4-aminophenyl)-N-methylacetamide)
Molecular Formula:
C22H30N6O2

Demethyl piperazine Nintedanib

CAS No: NA
Chemical Name:
(Z)-methyl 3-((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C30H31N5O4

Ethyl piperazine Nintedanib

CAS No: NA
Chemical Name:
(Z)-methyl 3-((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C32H35N5O4

Impurity-1/EP-C

CAS No: 1168150-46-6
Chemical Name:
(E)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C18H15NO4

Acid impurity/EP-B

CAS No: 894783-71-2
Chemical Name:
(Z)-3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid
Molecular Formula:
C30H31N5O4

Hydroxy impurity

CAS No: 2093243-16-2
Chemical Name:
(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Molecular Formula:
C17H13NO4

N,N-Dioxide

CAS No: 2734676-68-5
Chemical Name:
(Z)-1-(2-((4-((6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methylamino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
Molecular Formula:
C31H33N5O6

Reference standared

CAS No: 656247-18-6 656247-17-5( free base)
Chemical Name:
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate
Molecular Formula:
C33H39N5O7S